Posters

ACoP will not be providing printed poster abstracts at the meeting. Individuals who desire a printed copy of the abstracts may download this ZIP file (12.5 MB) containing all individual poster abstracts as Word documents. Alternately, single poster abstracts are available by clicking on a title below.

Poster presenters may find their poster location and presentation slot in this spreadsheet.  Click HERE for information on the layout of the posters and a map of the room.

Posterboard dimensions are 4 feet (~122 cm) wide by 8 feet (~244 cm) high (portrait orientation)- note, this is different than last year's meeting!  You may make your poster any size that fits within this area.

Name Abstract Poster Authors Topic
Anson Kunjachan Abraham Role of Receptor Dimerization and Specific Tissue Distribution in Target-Mediated Drug Disposition Models.  poster Anson K. Abraham and Donald E. Mager Biologics
Sima Ahadieh Model-Based Meta-Analysis of Young Maniac Rating Scale in Bipolar Patients  poster Sima Ahadieh, Thomas Tensfeldt Disease Modeling
Jae Eun Ahn Longitudinal Model-Based Meta-Analysis with NONMEM Poster Jae Eun Ahn, Jonathan French Tools and Techniques
Sihem Ait-Oudhia Comparison of Pharmacokinetics of Epoetin Alfa Following Multiple Subcutaneous Administrations in Healthy Volunteers and Anemic Cancer Patients Poster Sihem Ait-Oudhia, An Vermeulen, Wojciech Krzyzanski Special populations
Fatemeh Akhlaghi Blood and Plasma Pharmacokinetics of Bortezomib in Relation to Blood 20S Proteasome Activity after Single and Multiple Dosing in Cynomongolus Monkeys. Fatemeh Akhlaghi, Johan Monbaliu, Vic Kadambi, Li Yu Exposure-Response
Fatemeh Akhlaghi Development of an Integrated Pharmacokinetic and Pharmacodynamic Model for Bortezomib to Allow Predication of 20S Proteasome Activity from Plasma Concentrations Fatemeh Akhlaghi, Johan Monbaliu, Vic Kadambi, Shimoga Prakash, Frank Lee, and Li Yu. Mechanistic Modeling/Systems Biology
Charles Apelian MODESIM – A high-performance computing environment for pharmacometrics and beyond Poster Charles Apelian*, Colin Pillai, David James, Justin Wilkins, Celine Dartois, Anthony Rossini Tools and Techniques
Kyle Baron Pharmacometric Basis for a Fludarabine Test Dose Strategy in Nonmyeloablative Hematopoietic Stem Cell Transplantation Poster Kyle Baron, Janel Long-Boyle, Pamala Jacobson, Claudio Brunstein, Daniel Weisdorf, Richard Brundage Clinical Pharmacokinetics
Paul Baverel Informativeness of Internal and External Validation Techniques in Various Simulation Settings and Across Algorithms Poster Paul G Baverel*, Kristin E Karlsson, Mats O Karlsson  Tools and Techniques
Caroline Bazzoli Prediction of power of test of discrete covariates in population analyses and influence of design: application to gender effect in joint pharmacokinetic models of nucleoside analogs and their active metabolites Poster Caroline Bazzoli*, Sylvie Retout, France Mentré Study Design/Conduct
Margherita Bennetts Simulation Methodology for Quantitative Study Decision Making with R/NONMEM6 Poster Meg Bennetts, Byron Jones Tools and Techniques
Martin Bergstrand Prediction Corrected Visual Predictive Checks poster Martin Bergstrand, Andrew C. Hooker, Johan E. Wallin, Mats O. Karlsson Tools and Techniques
Robert Bies Public Health Model For The Evaluation Of The Management Of Hypertension – A Proposal Poster Yuyan Jin, Robert Bies*, Rajanikanth Madabushi, Norman Stockbridge, Jogarao Gobburu Public Health Outcomes
James R. Bosley, Jr. Pharmacokinetic Modeling, Simulation, and Scaling of Adult and Pediatric Data to Support International Regulatory Submissions Poster Brian Sadler, Jim Bosley* Pediatrics
Satjit Brar Hemodynamic Determinants of Clinical Endpoints in Pulmonary Arterial Hypertension Trials Poster Satjit Brar*, Pravin Jadhav, Norman Stockbridge, Jogarao Gobburu and Rajanikanth Madabushi Disease Modeling
Jurgen Bulitta Population Pharmacodynamic Modeling of the Mechanism of Action and Emergence of Sub-populations of Pseudomonas aeruginosa for a Wide Range of Colistin Dosage Regimens  poster Jürgen B Bulitta*, Phillip J Bergen, Brian T Tsuji, Jian Li, Roger L Nation, Alan Forrest  Mechanistic Modeling/Systems Biology
Jürgen Bulitta Mechanism-based Modeling of Beta-lactam Antibiotics Binding to Specific Penicillin-Binding Proteins of Pseudomonas aeruginosa at Several Initial Inocula  poster Jürgen B Bulitta*, Neang S Ly, Alan Forrest, Rebecca E D’Hondt, Brian T Tsuji  Mechanistic Modeling/Systems Biology
Wonkyung Byon Exposure-Response Analyses of the Effects of Pregabalin Administration in Patients with Fibromyalgia using Daily pain Score and Patient Global Impression of Change Poster Wonkyung Byon, Daniele Ouellet, Marci Chew, Kaori Ito, Paula Burger, Lynne Pauer, Bernhardt Zeiher, Brian Corrigan Exposure-Response
TJ Carrothers Population Models Correlating Exposure to Efficacy and Safety Markers following Oral Administration of a Novel Fructose-1,6-Bisphosphatase Inhibitor in Type 2 Diabetic Subjects Poster TJ Carrothers*, Joseph Walker, Tatiana Khariton, Bahru Habtemariam, Donald Mager, Shashank Rohatagi  Exposure-Response
Hongseok Chae Comparing simulated responses to risperidone and extended release (ER) paliperidone Poster Hongseok Chae, Byungjin Ahn, Seunghoon Han, Jimyun Kim, Kichan Do, Dong-Seok Yim Clinical Pharmacokinetics
Pascal Chanu Decisive support of Modeling & Simulation for getting drug approval in the context of safety concern on the drug class Poster Pascal Chanu*, Bruno Reigner, Nathalie Schultze, Ronald Gieschke, Jean-Eric Charoin, Nicolas Frey Clinical Outcome Modeling
Sunny Chapel Semi-mechanistic Model for Characterizing the Effect of Rifampin Co-administration on the Pharmacokinetics of Efavirenz Poster Sunny Chapel*, Jenny Zhang, Min Zhu (†), Amit Roy, Edward Acosta, Rick Bertz and Marc Pfister  Mechanistic Modeling/Systems Biology
Chunlin Chen Modeling of The Intravascular Mixing Phase of Neuromuscular Blocking Agents Following Intravenous Bolus Injection Poster Chunlin Chen*, François Donati and France Varin Clinical Pharmacokinetics
Craig M Comisar Determination of Operating Characteristics and Performance Requirements for a Vancomycin Forecasting Algorithm Used for Clinical Decision Support in Pediatric Patients. Poster Craig M. Comisar, Bhuvana Jayaraman, Jeffrey S. Barrett Pediatrics
Demiana William Faltaos Estimation of Population Pharmacokinetic Parameters Using MLXTRAN Interpreter in MONOLIX 2.4 Poster Demiana William Faltaos*, Ping Ji, Pravin Jadhav, Hao Zhu . Tools and Techniques
Sameer Doshi Clinical Trial Simulations to Evaluate Non-Inferiority of Hemoglobin Response Comparing Once Monthly to Every Two Week Dosing of Darbepoetin Alfa Poster Sameer Doshi, Juan Jose Perez Ruixo Clinical Outcome Modeling
Anne Dubois Model-based analyses of crossover trials: extension of the SAEM algorithm in MONOLIX software and evaluation of Wald and likelihood ratio tests Poster Anne Dubois*, Marc Lavielle, Sandro Gsteiger, Etienne Pigeolet and France Mentré Tools and Techniques
James Dunyak Modeling Enterohepatic Recirculation and Intestinal Lumen Exposure for a Compound with Substantial Accumulation Poster James Dunyak Clinical Pharmacokinetics
Sandeep Dutta Population Pharmacokinetics of ABT-594 in Subjects with Diabetic Peripheral Neuropathic Pain Poster Sandeep Dutta, Walid M Awni Clinical Pharmacokinetics
Sandeep Dutta Population Pharmacokinetics and Exposure Response of Valproic Acid in Mania Associated with Bipolar Disorder-A Combined Analysis of Two Placebo-Controlled Phase 3 Trials Poster Sandeep Dutta, Paul M. Diderichsen Exposure-Response
Sandeep Dutta Population Analyses of Efficacy and Safety of ABT-594 in Subjects with Diabetic Peripheral Neuropathic Pain Poster Sandeep Dutta, Balakrishna S Hosmane, Walid M Awni Exposure-Response
Andrea Edginton Physiologically-based Modeling for Predicting Pharmacokinetic Changes under Physiological Stressors Poster Henry T. Peng, Andrea Edginton, Bob Cheung Special populations
Farkad Ezzet A Mixed-Effects Hazard Model to Compare the PK/PD of Armodafinil and Modafinil in Patients with Excessive Sleepiness Associated with Shift Work Disorder Poster Farkad Ezzet*, Lauren Young, Mona Darwish  Exposure-Response
Frédérique Fenneteau Physiologically based predictions of the impact of inhibition of intestinal and hepatic metabolism on human pharmacokinetics of CYP3A substrates Poster Frederique Fenneteau, Patrick Poulin, Jun Li, Fahima Nekka Mechanistic Modeling/Systems Biology
Immanuel Freedman Feasibility of Immunogenicity Assessment Based on Models of Polyclonal Anti-Drug Antibody Immunodynamics  poster Immanuel Freedman*  Biologics
Immanuel Freedman Bayesian Parametric Schild Analysis of Data from a Whole Blood Stimulation Assay.  poster Immanuel Freedman*, Feng Liu, Daren Austin, Erika de Boever, Jenny Craigen, Marie Davies, Neil Brewis, and the Study Team. Exposure-Response
Jonathan French MSToolkit – An R library for simulating and evaluating clinical trial designs and scenarios  poster Mike K Smith, Richard Pugh, Romain Francois, Jonathan French Tools and Techniques
Parag Garhyan Poster: Population Pharmacokinetic Modeling of Enzastaurin and its Major Metabolite in Healthy Subjects and Cancer Patients Poster Parag Garhyan*, John Baldwin, Pamela Welch, Donald Thornton Clinical Pharmacokinetics
Tushar Garimella Population Pharmacokinetic Analysis of ABT-089, a Neuronal Nicotinic Receptor Agonist, in Elderly Subjects with Alzheimer’s Disease and in Healthy Adult Subjects Poster Tushar Garimella,Robert Lenz, Walid Awni, Sandeep Dutta Clinical Pharmacokinetics
Christine Garnett Influence of Gender and Study Design on Moxifloxacin Concentration-QT Relationship Poster Jeffry A. Florian Jr, Christoffer W. Tornoe, Richard Brundage, and Christine E. Garnett* Exposure-Response
Marc Gastonguay BUGSModelLibrary: A Prototype Model Library for Bayesian PKPD Modeling in WinBUGS  poster William R Gillespie*, Marc R Gastonguay Tools and Techniques
Marc Gastonguay Development and Pilot Evaluation of a High-Performance Computing System for Web-Based Deployment of Pharmacometrics Applications in a Multi-User Training Environment.  poster Timothy Bergsma*, Jeffrey Hall, Malaz A. AbuTarif, David R. Taft, William Knebel, Joseph Hebert, James Rogers, Jeffrey T. Hane, and Marc R. Gastonguay Tools and Techniques
Parviz Ghahramani Population Pharmacokinetic Analysis of Milnacipran in Fibromyalgia Patients and Healthy Volunteers Poster Parviz Ghahramani* and Antonia Periclou Clinical Pharmacokinetics
Leonid Gibiansky Mechanistic Interpretation of Indirect-Response Models for Drugs with Target-Mediated Disposition  poster Leonid Gibiansky, Ekaterina Gibiansky Biologics
Leonid Gibiansky Target-Mediated Drug Disposition Model for Drugs with Multiple Targets  poster Leonid Gibiansky, Ekaterina Gibiansky Biologics
Ihab G. Girgis Pharmacokinetic-Pharmacodynamic Assessment of Topiramate Adjunctive Therapy in Epilepsy  poster Ihab G. Girgis, Partha Nandy, Jeffrey S. Nye, Lisa Ford, Steven Wang, and Eugène Cox Exposure-Response
Varun Goel Application of Active-Comparator Based Benefit-Risk Assessment in Evaluating Clinical Trial Design Features of a New Chemical Entity in a Bayesian Decision Theoretic Framework Poster Varun Goel, Brian Corrigan, Raymond Miller, Timothy E Hanson, Richard C Brundage Benefit/Risk Assessment
Thaddeus Grasela Forensic Pharmacometrics: Part 1 - Data Assembly Poster Thaddeus H. Grasela, Jill Fiedler-Kelly, Darcy J. Hitchcock, Elizabeth A. Ludwig, Julie A. Passarell Quality Assurance, Forensic Pharmacometrics
Michelle Green Quantitative Understanding of the Impact of Evolving Rescue Criteria in the Assessment of Anti-diabetic Compounds Poster Michelle L. Green, T. J. Carrothers Clinical Outcome Modeling
Anita Grover Determination of the Operational Multiple Dosing Half Life Poster Anita Grover, Leslie Z. Benet Tools and Techniques
Yaming Hang Comparison of Generalized Additive Model and Wald's Approximation Method for Covariate Selection in Population Pharmacokinetic Analysis Poster Yaming Hang, Kuenhi Tsai, Alan Hartford Tools and Techniques
Emma Hansson Correlations Between Fatigue, Hand-foot syndrome and the Angiogenic Factors VEGF, sVEGFR-2, sVEGFR-3 and sKIT in Patients Receiving Sunitinib Poster Guangli Ma, Emma K. Hansson *, Michael Amantea, Peter A. Milligan, Lena E. Friberg, Mats O. Karlsson  Exposure-Response
John Harrold Mechanistic Modeling of Combination Rituximab and rhApo2L Chemotherapy in Mice Bearing Ramos Lymphoma Xenografts Poster John Harrold and Donald Mager Mechanistic Modeling/Systems Biology
Michael Heathman Interactive Simulation and Visualization of Drug/Disease Models Poster Michael Heathman, Donald Jennings, and Bernett Lee Tools and Techniques
Gabriel Helmlinger Inference of imatinib (IM) effects on leukemic stem cell (SC) compartment via mathematical modeling of IRIS treatment response data Poster Dean Bottino, Yen Lin Chia, Andrew Stein, Anna Georgieva, Gabriel Helmlinger, Thea Kalebic Mechanistic Modeling/Systems Biology
Ying Hong Model-based Analysis to Propose Atazanavir Doses for HIV-Infected Pediatric Patients Poster Ying Hong, Kenneth Kowalski, Amit Roy*, Li Zhu, Jenny Zhang, Jennifer Kiser, Courtney Fletcher, Maria-Arantxa Horga, Richard Rutstein, Richard Bertz, Marc Pfister  Pediatrics
Xiaoli S. Hou D-optimal Design for PK Modeling Poster Xiaoli S. Hou*, Bo Jin, Nancy Agrawal  Tools and Techniques
Joy C. Hsu Population Pharmacokinetics of PLX4032, a highly selective V600E BRAF kinase inhibitor, in Healthy Volunteers Poster Joy C. Hsu, Micha Levi, Joseph F. Grippo, Ruben Ayala, Keith Nolop, Nicolas Frey Clinical Pharmacokinetics
Kaori Ito Disease Progression Analysis from ADNI Database in Normal, MCI and Alzheimer’s Disease Patients. Poster Kaori Ito, Brian Corrigan, Qinying Zhao, Jonathan French, Raymond Miller, Holly Soares, Elyse Katz, Timothy Nicholas, Bill Billing, Richard Anziano, Terence Fullerton and the Alzheimer’s Disease Neuroimaging Initiative. Disease Modeling
David A James ABPM: A statistical package for the visualization, analysis and modeling of ambulatory blood pressure data Poster David A. James, Xiaoyong Sun, Ramesh Sarangapani, Deborah Keefe Tools and Techniques
Seong Bok Jang The Use of Truncated Area under the Curve as a Measure of Relative Extent in Bioequivalence Studies Poster Seong Bok Jang*, Yoon Jung Lee, Lay Ahyoung Lim, Kyungsoo Park Clinical Pharmacokinetics
Frank Jen Characterizing Nelfinavir Pharmacokinetic Changes During Pregnancy in HIV-Infected Women – Modeling and Simulations in Study Design Poster Juif (Frank) Jen*, Annie Fang, Bharat Damle Special populations
Ping Ji Modeling of Rich Pharmacokinetic Datasets Using SAEM Algorithm Implemented in MONOLIX 2.4 Poster Ping Ji, Demiana William Faltaos, Pravin Jadhav, Hao Zhu Tools and Techniques
Joseph Kahn Simulation Manager in R for Modeling and Decision Analysis Poster Joseph Kahn*, Sourav Das, Derek Ayers, Richard Nixon, Joyee Ghosh Tools and Techniques
Nitin Kaila A Pharmacodynamic Model for the Long Term Effects of Galvus, Metformin and a combination therapy of Galvus with Metformin on Fasting Plasma Glucose (FPG) and Glycosylated Hemoglobin A1c (HbA1c) in patients with Type II Diabetes Patients (T2DM) Poster Amit Khatri, William Ebling, Ramesh Sarangapani, Nitin Kaila Disease Modeling
Nitin Kaila A Methodological Approach For Projecting Blood-Pressure Dose Response For A Backup Compound Using Clinical And Biomarker Data From A Previously Studied Agent In The Same Class Poster Nitin Kaila, William Ebling, Charles Meyers, Ramesh Sarangapani Exposure-Response
Mohamed A Kamal Application of Bayesian Feedback Analysis to Test Competing Hypotheses of Discrepancy between Single and Multiple Ascending Dose Pharmacokinetic Data Poster Mohamed Kamal, Vishak Subramoney, Ahmad Mokatrin, Michael Derby, Lois Lee, Nicolas Frey Tools and Techniques
Kristin Karlsson Performance of the LAPLACE method in repeated time-to-event modeling Poster Kristin E. Karlsson, Elodie L. Plan, Mats O. Karlsson Event Driven Non-continuous Data Models
Helen Kastrissios A Population Pharmacokinetic Model for a Novel Oral Hypoglycemic Formed In Vivo: Comparing the Use of Active Metabolite Data Alone versus Using Data of Upstream and Downstream Metabolites Poster Helen Kastrissios*, Joseph Walker, Tatiana Khariton, Smita Kshirsagar, Bahru Habtemariam, Donald Mager, Shashank Rohatagi  Special populations
Amit Khatri Evaluation of Drug Administration Sequence Effects on Tumor Cell Kill Using WBDiff in WinBUGS Poster Amit Khatri, Brent Williams, Jessica Huxtable, Richard Brundage, Douglas Yee, Mark Kirstein. Exposure-Response
Hyewon Kim Population Pharmacokinetics of Unbound Mycophenolic Acid in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation (HCT) Poster Hyewon Kim*, Janel Long-Boyle, Nancy Rydholm, Paul Orchard, Jakub Tolar, Pamala Jacobson, Richard Brundage  Pediatrics
Tae Eun Kim The evaluation of the impact of in vitro dose-response curve slope on the clinical antiviral activity prediction of an HIV drug using PK-PD-Disease model-based simulation Poster Tae Eun Kim, Gary Pollack, Joseph Kim Exposure-Response
Yoon Gyoon Kim Population pharmacokinetics of PD 0200390, a new calcium channel alpha-2-delta subunit-binding compound Poster Yoon Gyoon Kim, Brian Corrigan, Raymond Miller Clinical Pharmacokinetics
Holly Kimko In Vitro – In Vivo Correlation of Extended Release Tablets to Support Proposed Bioequivalence Specifications Poster Holly Kimko*, Linda Pors, Partha Nandy, Adrian Dunne Tools and Techniques
Sriram Krishnaswami PK/PD of Celecoxib in Pediatric Patients with Juvenile Rheumatoid Arthritis Poster Sriram Krishnaswami*, Matt Hutmacher, Hong Wang, Akintunde Bello, Christine West Exposure-Response
Cornelia Landersdorfer Population PK/PD Modeling of the Effects of Vildagliptin on Active GLP-1, Glucose, and Insulin Poster Cornelia B. Landersdorfer*, Yan-Ling He, Lise Kjems, William J. Jusko Mechanistic Modeling/Systems Biology
Cornelia Landersdorfer Pharmacodynamic Modeling of the Effects of Tetraiodothyroacetic Acid (Tetrac) on Human Cancer Cell Proliferation Poster Cornelia B. Landersdorfer*, Heng-Yuan Tang, Mingzeng Sun, David London, Ran Meng, Cassie Lin, Lurdes Queimado, Shaker A. Mousa, George Drusano, Arnold Louie, Faith B. Davis, Hung-Yun Lin, Paul J. Davis. Mechanistic Modeling/Systems Biology
Jean R. Lavigne Simultaneous Modeling and Simulation of Glucagon, Glucose and Insulin Poster Jean R Lavigne, Anna Maria Schinas, Tim Stewart, Kathryn Cairati, Bernice Welles Mechanistic Modeling/Systems Biology
Joo-Yeon Lee Evaluation of Bayesian adaptive designs for dose-finding studies via computer simulations Poster Joo-Yeon Lee, Yaning Wang Study Design/Conduct
Tarek A. Leil Trial Simulation to Assess the Effect of Patient Compliance on Potential Outcomes in Population PK Studies  poster Tarek Leil, Linh Van, Marc Pfister, Liping Zhang Study Design/Conduct
Micha Levi A mechanistic target mediated drug disposition (TMDD) model is required to correctly estimate the bioavailability of a subcutaneous formulation of Tocilizumab (TCZ), a monoclonal antibody with non-linear kinetics Poster Micha Levi*, Jean-Eric Charoin, Nicolas Frey, Isabelle Delor, Philippe Jacqmin  Mechanistic Modeling/Systems Biology
Fang Li Pharmacometrics-Based Dose Selection of Levofloxacin as a Treatment for Post-Exposure Inhalational Anthrax in Children Poster Fang Li*, Partha Nandya, Shuchean Chienb, Christoffer Tornoe Pediatrics
Fang Li Implementation of Computer Cluster for Pharmacometric Analyses at FDA Poster Fang Li*, Peter Lee, Joga Gobburu, Christoffer Tornoe Tools and Techniques
Hanbin Li Pharmacokinetics Nomograms For The Onset And Offset Of Postoperative Dental Pain Relief with Ibuprofen  poster Hanbin Li, Jaap Mandema, Russell Wada, Shyamalie Jayawarden, Paul Desjardins, Geraldine Doyle, David Kellstein Clinical Outcome Modeling
Jun Li A new estimation approach for in vivo antimicrobial drug efficacy accounting for variability in pharmacokinetics Poster Jun Li, Denis Gohore bi, Frédérique Fenneteau and Fahima Nekka Mechanistic Modeling/Systems Biology
Xiujiang (Susie) Li Population PK/PD Modeling of Efficacy and Safety of CB1R Inverse Agonist Taranabant in Obese Patients Poster Xiujiang Susie Li*, Bo Jin, Lanyan Fang, Huafeng Zhou, Julie Passarell, Qiang Lu, Jing Su, Carol Addy, Ngozi Erondu, Shailaja Suryawanshi, Jill Fiedler-Kelly, Julie Stone  Exposure-Response
Lars Lindbom A Drug Independent Tumor Size Reduction-Survival Model in Advanced Ovarian Cancer to Support Early Clinical Development Decisions  poster Lars Lindbom, Laurent Claret, Valerie Andre, Ann Cleverly, Dinesh de Alwis, Rene Bruno Disease Modeling
Joerg Lippert Development of a generic physiologically-based pharmacokinetics model for protein therapeutics in PK-Sim® Poster Christoph Niederalt, Stefan Willmann, Lars Kuepfer, Thomas Eissing, Juri Solodenko, Jörg Lippert* Biologics, Mechanistic Modeling
Joerg Lippert Multi-scale PK/PD modeling and simulation using PK-Sim® and MoBi®: A mechanistic whole-body pharmacogenomics model of tumor growth and cytostatic intervention Poster Thomas Eissing, Michael Block, Katrin Coboeken, Thomas Gaub, Lars Kuepfer, Michaela Meyer, Michael Sevestre, Juri Solodenko, Joerg Lippert* Mechanistic Modeling/Systems Biology
Joerg Lippert A Generic Translational Approach to Pediatric Study Design Relying on Whole-Body Physiologically-Based Pharmacokinetic Modeling Poster C. Becker, S. Willmann*, T. Eissing, R. Burghaus, J. Lippert, G. Ahr, H. Stass Pediatrics
Joerg Lippert Mechanism-based Prediction of Particle-Size Dependent Dissolution and Absorption Kinetics with PK-Sim® Poster Stefan Willmann*, Kirstin Thelen, Corina Becker, Jennifer B. Dressman, Joerg Lippert  Tools and Techniques
Joerg Lippert Unified statistical and physiologically-based modeling with PK-Sim® and MoBi®: PBPK meets NLME and MCMC Poster Linus Görlitz, Michael Block, Rolf Burghaus, Jörg Lippert * Tools and Techniques
Jing Liu Semi-Mechanism Based Nonlinear PK Modeling and Scaling of a Fully Human Antibody in Cynomolgus Monkeys Predicts the Nonlinear PK in Healthy Volunteers Poster Jing Liu*, Susan Hurst, Seth Sadis, Steve Olson, Matt Devalaraja, Jim Mobley, Wenlian Wang, Rosonald Bell, Melba Dokmanovich, William Maier, Ron Fedechko, Arnab Mukherjee, Jeffrey R. Koup Biologics
Wei Liu Time-Dependent, Dual First and Zero-Order Absorption Model for Characterizing the Delayed Absorption Profile in Subjects with Acute Pain Poster Wei Liu*, Paul M. Diderichsen, Peter A. Noertersheuser, Walid Awni, Sandeep Dutta Clinical Pharmacokinetics
Wei Liu Modeling “Pain Memory” is Central to Characterizing the Hazard of Dropping Out in Acute Pain Studies Poster Paul M. Diderichsen*, Sandeep Dutta, Wei Liu, Peter A. Noertersheuser, Walid Awni Event Driven Non-continuous Data Models
Rocio Lledo-Garcia A New Whole Body Clinical Physiologically-Based Pharmacokinetic Model (WB-PBPK) for Estimation of PK Parameters with Informative Prior Distribution in Nonmem Poster Rocío Lledó-García*, Lotfi Slimani  & Mats O. Karlsson  PBPK modeling
Mark Lovern Use of a Short-Term Viral Dynamic Model to Predict Long-Term Clinical Outcome in Patients Receiving Anti-Retroviral Therapy for HIV-1 Infection Poster Mark Lovern*, Roberto Gomeni, Joannellyn Chiu Clinical Outcome Modeling
Jian-Feng Lu Population Pharmacokinetic (PK)/Pharmacodynamic (PD) Modeling and Simulations for Exposure–Tumor Response Relationships: Motesanib in a Phase 2 Thyroid Cancer Study Poster Jian-Feng Lu*, Laurent Claret, Liviawati Sutjandra, Mita Kuchimanchi, Daniel E. Stepan, Rene Bruno, Rebeca Melara, Yu-Nien Sun  Exposure-Response
Yasong Lu Modeling-Aided Human-to-Animal Translation of the Anticonvulsant Retigabine, a Kv7.2-5 Channel Opener Poster Yasong Lu*, Haojing Rong, Cheryl Li, Lauren Quattrochi, Emily Hudson, Polina Stolyar, Kevin Serpa, Robert Dunn, Robert J. Mather Mechanistic Modeling/Systems Biology
Zheng Lu Pharmacokinetic – Pharmacodynamic modeling of Tumor Growth Data from Mice Following Administration of Drug Candidate Poster Z. Lu*, Kha Le, Frank Lee, Yang Hua Mechanistic Modeling/Systems Biology
Kenneth T. Luu A Pharmacokinetic and Tumor-Immune Interaction Model for Immunomodulating Antibodies Poster Kenneth T. Luu, Paolo Vicini Biologics
Nitin Mehrotra Value of collecting PK in late phase clinical trials Poster Nitin Mehrotra*, Yaning Wang  Drug Development
Zhaoyu (Amy) Meng Pharmacokinetic Modeling of Etomidate: A Randomized Comparison of Two Formulations Poster Zhaoyu Meng*, Matthew Chan, Tony Gin Clinical Pharmacokinetics
France Mentré Parameter estimation of long-term HIV dynamic model in the COPHAR2 – ANRS 111 trial using MONOLIX  poster Marc Lavielle, Adeline Samson, Ana Karina Fermin, France Mentré*  Mechanistic Modeling/Systems Biology
France Mentré Evaluation of different tests based on observations for external model evaluation of population analyses  poster France Mentré*, Karl Brendel, Emmanuelle Comets  Tools and Techniques
Helen Moore Mathematical optimization of therapies for chronic hepatitis C virus (HCV) infection Poster Helen Moore Tools and Techniques
Diane R Mould Population Pharmacokinetic Modeling and Simulation in Treatment of Seizures in Infants with Topiramate  poster Diane R. Mould, Partha Nandy, Ihab G. Girgis, Eugene Cox, Seth Ness, Lisa Ford Special populations
Song Mu Modeling longitudinal tumor metrics in NHL patients treated with Rituximab: Application of the Norton-Simon Hypothesis incorporating Gompertzian growth Poster Song Mu, Jianmei Wang, Jing Li, Jennifer Visich, Franziska Schaedeli-Stark, Nancy Valente, Mike Burgess, Michael Wenger, Tim Goggin Disease Modeling
Partha Nandy Evaluation of Exposure-response in Flexible Dose Clinical Trials: Comparison of Mixed Model Repeated Measures (MMRM) and Marginal Structural Models (MSM) via a Simulation Study Poster Xu (Steven) Xu, Nandy Partha *, Julia Wang  Tools and Techniques
Lauren Neal Theoretical and experimental comparison of hepatitis C viral dynamics models and parameter estimates Poster Lauren Neal and Pravin Jadhav Disease Modeling
Srividya Neelakantan Population Pharmacokinetic Analysis of Dalbavancin in Patients with Skin and Skin Structure Infections Poster Srividya Neelakantan*, Vivek S Purohit, Bruce Green, Thomas G Tensfeldt, Diane R Mould  Clinical Pharmacokinetics
Fahima Nekka Evaluation of the Pharmacological Effect Induced by Patient Irregular Drug Intake Poster Jun Li and Fahima Nekka Mechanistic Modeling/Systems Biology
Chee M Ng Simulated Annealing Monte-Carlo Parametric Expectation Maximization Estimation Method for Population Pharmacokinetic/Pharmacodynamic Data Analysis Poster Chee M Ng, Robert J Bauer Tools and Techniques
Chee M Ng Global Optimization and Pattern Search-based Optimization Algorithms for Parameter Estimation in Complex Pharmacokinetic/Pharmacodynamic Data Analysis Poster Chee M Ng Tools and Techniques
Thu Thuy Nguyen Design evaluation and optimization in crossover pharmacokinetic studies analyzed by nonlinear mixed effects models. Application to bioequivalence or interaction trials.  poster Thu Thuy Nguyen, Caroline Bazzoli, France Mentré. Study Design/Conduct
Timothy Nicholas Preliminary Population Pharmacokinetic Modeling of PF-04360365, a Humanized Anti-Amyloid Monoclonal Antibody, in Patients with Mild-to-Moderate Alzheimer’s Disease Poster Timothy Nicholas,* William Knebel, Marc R Gastonguay, Martin M Bednar, Clare B Billing Jr, Jaren W Landen, James W Kupiec, Brian Corrigan, Rene Laurencot, and Qinying Zhao Clinical Pharmacokinetics
Dana Nickens A Model-based Dose-response Meta-analysis of Single Agent Intraocular Pressure (IOP) Therapies Used to Evaluate Efficacy of a Potential New Therapy (PF-03187207) in Glaucoma Patients Poster Dana Nickens*, Jaap Mandema, Rachel Courtney, Susan Raber, Charles Bosworth Model-based meta analysis
Gianluca Nucci Model-Based Meta-Analysis of Concentration-D2 Occupancy in Healthy Volunteers and Schizophrenic Patients  poster Gianluca Nucci, Jaap Mandema Exposure-Response
Joakim Nyberg Optimal design on Time-To-Event models with an emphasis on dropouts in Disease Progression studies Poster Joakim Nyberg, Anna Svensson, Mats O. Karlsson, Andrew C. Hooker Study Design/Conduct
Daniele Ouellet Semi-Physiological Population PK/PD Modeling of Eltrombopag in Healthy Volunteers and Patients with Idiopathic Thrombocytopenic Purpura Poster Siobhan Hayes, Daniele Ouellet, Jianping Zhang, Mary Wire, Ekaterina Gibiansky Exposure-Response
John Carl Panetta A Mathematical Model of Intracellular Methotrexate Accumulation and the Inhibition of Folate Pathway Enzymes in Acute Lymphoblastic Leukemia Poster John C Panetta, Alex Sparreboom, Ching-Hon Pui, Mary V Relling, William E Evans Clinical Pharmacokinetics
Paul Panorchan Evaluation of the Dose-Response Relationship to Short-term Monotherapy with the HCV Protease Inhibitor, MK-7009 Poster Paul Panorchan, Robert Nachbar, Jeff Saltzman, Anis Khan, David Olsen, Erin Quirk, Richard Barnard, Peggy Hwang, Hamish Wright, Julie A. Stone Exposure-Response
Michael Pelekis Mechanistic Evaluation of the Population Systemic Exposure Related to the Use of Acetaminophen using GastroPlus™ Poster Michael Pelekis*, Viera Lukacova, Grazyna Fraczkiewicz, John Crison, Walt Woltosz Mechanistic Modeling/Systems Biology
Juan Jose Perez Ruixo Characterization of Platelet Cell Turnover in Thrombocytopenic Adults with ITP using a KPD model Poster Juan Jose Perez Ruixo, Bruce Green, Sameer Doshi, Yow-Ming Wang, Diane Mould Exposure-Response
Klas Johan Fredrik Petersson Comparisons of modeling dropout as Time-to-Event data or Binary data using logistic regression. Poster Klas J F Petersson, An M Vermeulen, Lena E Friberg Event Driven Non-continuous Data Models
Elodie Plan Repeated Time-to-Categorical Events analysis Poster Elodie L. Plan*, Kristin E. Karlsson, Mats O. Karlsson  Event Driven Non-continuous Data Models
Bill Poland Optimal Sequencing of Interdependent Drug Development Programs Poster Bill Poland Tools and Techniques
Ruolun Qiu Modeling and Simulation of Plasma Abeta in Human After Multiple Oral Doses of PF-3084014, A Potent Gamma Secretase Inhibitor Poster Ruolun Qiu, Susan Willavize, Terence Fullerton  and Marc R. Gastonguay  Exposure-Response
Tonya Quinlan Pharmacokinetic/Pharmacodynamic Modeling of the Effects of Duloxetine on 3,4-dihydroxyphenylglycol (DHPG) in Plasma and Cerebrospinal Fluid in Healthy Subjects Poster Tonya Quinlan, Mary Pat Knadler, Beth Pangallo, Jill Chappell, Evelyn Lobo Exposure-Response
Ramprasad Ramakrishma Evolving an Infrastructure to build and maintain indication- specific summary-level literature databases to support model based drug development Poster Hugh McDevitt, Goonaseelan Pillai, Gerard JP Flesch, Ramprasad Ramakrishna*, Georges Ette, Sreeni Devidas, Rajasekhar Thatavarti, Vincent Buchheit Tools and Techniques
Ramprasad Ramakrishna Meta-analysis of Summary-level Literature Data Integrated with Sponsor Data to Support Model Based Drug Development. Poster Didier Renard, Ramprasad Ramakrishna*, Goonaseelan Pillai, Gavin Miyasato, James Dunyak, William Ebling, Kai Wu Clinical Outcome Modeling
Ramprasad Ramakrishna The RAAS PhysioLab model of hypertension: Development and parameterization of normotensive and hypertensive virtual patients (VPs), and generation of virtual populations (Vpops). Poster Arthur Lo, Jennifer Beh, Sergey Ermakov, Saroja Ramanujan, Manoj Rodrigo, Hector De Leon, Ramprasad Ramakrishna *, Anna Georgieva, Gabriel Helmlinger, Deborah Keefe, Alan Charney,William P. Dole, David Feldman, Ramesh Sarangapani. Mechanistic Modeling/Systems Biology
Ramprasad Ramakrishna The RAAS Hypertension PhysioLab platform: A computer modeling platform to support design and analysis of clinical studies of novel antihypertensive therapies in a variety of clinical hypertensive phenotypes: Concepts and methodology. Poster Ramprasad Ramakrishna *, Anna Georgieva, Ramesh Sarangapani, Arthur Lo, Jennifer Beh, Sergey Ermakov, Manoj Rodrigo, Stuart Friedman, Gabriel Helmlinger, Deborah Keefe, Alan Charney,William P. Dole, David Feldman, Hector De Leon. Mechanistic Modeling/Systems Biology
Patanjali Ravva Population pharmacokinetic model of sulopenem and an oral prodrug, sulopenem etzadroxil, in man, including interaction with probenecid  poster Patanjali Ravva, Richard Upton, Diane R Mould and Anasuya Hazra Clinical Pharmacokinetics
Jakob Ribbing Use of a Non-Parsimonious Model for Study Design  poster Jakob Ribbing, Patrick J. Johnson, Virginie Herben, Gordon Graham, Thomas Kerbusch, Mats O. Karlsson Study Design/Conduct
Matthew M. Riggs A Systems Biology Model To Describe Long-Term Bone Remodeling Effects Of Estrogen In Menopausal And Postmenopausal Women. Poster Matthew M. Riggs, Mark C. Peterson, Marc R. Gastonguay Mechanistic Modeling/Systems Biology
Arne Ring Delayed Effects in the Exposure-Response Analysis of Clinical QT-Studies  poster Patricia Glomb, Arne Ring* Exposure-Response
James A. Rogers Population Dose-Response Model for ADAS-cog Scores in Patients with Alzheimer’s Disease by Meta-Analysis of a Mixture of Summary and Individual Data  poster William R. Gillespie, James A. Rogers, Kaori Ito, Marc R. Gastonguay Disease Modeling
James A. Rogers Clinical Trial Simulation to Compare Adaptive and Fixed Designs for a Phase 3 Clinical Trial of Nacystelyn® (L-Lysine-N-acetyl-L-cysteinate) for Cystic Fibrosis  poster James A. Rogers, Matthew M. Riggs, Monte Coffiner, William R. Gillespie, Robert Burford, Francis Vanderbist, Sophie De Niet, Marc R. Gastonguay Study Design/Conduct
Mark Sale Parallel Execution of NONMEM Poster Mark Sale, Sam Thomsen, Robert Bauer, Tom Ludden Tools and Techniques
Ahmed Salem Pharmacodynamic Assessment of Vancomycin-Rifampin Combination against Methicillin-Resistant Staphylococcus aureus Biofilm Poster Ahmed H. Salem*, Walid F. El-Khatib and Ayman M. Noreddin Exposure-Response
William M. Sallas Population Pharmacokinetics for Penciclovir in Infants and Children for Famciclovir Dosing Recommendations  poster William M. Sallas, Günther Kaiser, Kamal Hamed, Michael Looby Pediatrics
Mahesh N. Samtani Paliperidone Palmitate Dosing in Special Patient Populations Including the Elderly and those with Renal Impairment or Differing Body Mass Index: Guidance Based on Pharmacokinetic Modeling and Simulation  poster Mahesh N. Samtani, Srihari Gopal, Jennifer Kern Sliwa, J. Thomas Haskins, Larry Alph, Kim Stuyckens, An Vermeulen Clinical Pharmacokinetics, Special Populations
Mahesh N. Samtani Simple Pharmacometric Tools for Oral Anti-Diabetic Drug Development: Competitive Landscape for Oral Non-Insulin Therapies in Type 2 Diabetes  poster Mahesh N. Samtani Mechanistic Modeling/Systems Biology
Sachin Sanduja Interactive, scalable and modular framework for data analysis: An application to population pharmacokinetic modeling. Poster Sachin Sanduja, Deep Prakash, Abhishek Kumar, Neeraj Pant Tools and Techniques
Pratap Singh Mixed Effects Model Analysis of the QTc Interval-concentration Relationship of SC-080 in Healthy Subjects Poster Pratap Singh*, Steve Riley, Anup Zutshi, Brian Bond Exposure-Response
Julie Stone Viral Dynamics Modeling of Viral Load and Resistance Data from Short-term Monotherapy with the HCV Protease Inhibitor, MK-7009 Poster Julie A. Stone, Paul Panorchan, Robert Nachbar, Anis Khan, David Olsen, Richard Barnard, Peggy Hwang, Jeff Saltzman Disease Modeling
Herbert Struemper Estimation of the PK-Receptor Occupancy Relationship Based Upon PET Data with Large Test-Retest Variability.  poster Herbert Struemper, Stefano Zamuner, Roger Gunn, Graham Searle, Venkatesha Murthy, Daniele Ouellet. Exposure-Response
Michael Tagen Population Pharmacokinetic and Pharmacogenetic Analysis of Gefitinib in Pediatric Cancer Patients Poster Michael Tagen, Paula Schaiquevich, John C. Panetta, Najat C. Daw, Russell Geyer, Wayne Furman, Clinton F. Stewart Pediatrics
Stacey Tannenbaum A Methodology for Model-Based Bioequivalence of Two Manufacturing Variants of a Monoclonal Antibody poster Stacey Tannenbaum*, Abhijit Chakraborty, Christiane Rordorf , Phil Lowe  Biologics, Tools and Techniques
Stacey Tannenbaum Sharing Experiences of a Dedicated SAS Programming Group in a M&S Department poster Gregory Pinault, Goonaseelan Pillai, Jean-Louis Steimer, Stacey Tannenbaum, Hugh McDevitt, Vincent Buchheit Tools and Techniques
Christoffer W Tornoe Impact of Pharmacometric Reviews on New Drug Approval and Labeling Decisions—a Survey of 65 NDAs Between 2006 and 2008  poster Christoffer W Tornoe, Venkatesh Bhattaram, Justin C Earp, Christine Garnett, Jogarao Gobburu, Andre Jackson, Pravin Jadhav, Leslie Kenna, Manoj Khurana, Kevin Krudys, Joo-Yeon Lee, Peter Lee, Lawrence Lesko, Fang Li, Qi Liu, Rajanikanth Madabushi, Nitin Mehrotra, Young-Jin Moon, Srikanth Nallani, Yaning Wang, Hao Zhu Pharmacometrics review, Regulatory impact
Kuenhi Tsai Sensitivity Analysis on an IVIVC PK/PD Model Poster Ruosha Li, Kuenhi Tsai *, Lucy Fang  Sensitivity analysis
Scott Van Wart Impact of Dose Selection and Assay Sensitivity on Target Mediated Drug Disposition (TMDD) Population Pharmacokinetic Model Parameter Estimation: A Case Study Using Interferon-beta Poster Scott A. Van Wart, Anshu Marathe and Donald E. Mager Study Design/Conduct
France Varin Clinical Pharmacokinetics of Ropivacaine after Femoral Nerve Block in Patients Undergoing Total Knee Arthroplasty: Preliminary results.  poster Authors: Francois Gaudreault, Pierre Drolet, France Varin Clinical Pharmacokinetics
France Varin In vivo-In vitro correlation between early systemic exposure and delivered dose of inhaled milrinone using two types of nebulizers. Anne Q.N. Nguyen, André Y. Denault, Louis P. Perrault, France Varin*  Clinical Pharmacokinetics
Xiaoning Wang Dasatinib Exposure-Efficacy/Safety Analyses to Support Dose Regimen Recommendation for Patients with Chronic Myeloid Leukemia  poster Xiaoning Wang, Tai-Tsang Chen, Eric Bleickardt, Marc Pfister, Amit Roy Exposure-Response
Timothy Waterhouse Using Uncertainty in Exposure-Response Modeling and Simulation to Select Phase II Doses  poster Timothy Waterhouse, Charles Benson, Alan Chiang, Cheng Cai Tang Benefit/Risk Assessment
Susan Willavize Disease Progression of Cognitive Impairment in Alzheimer’s Disease: A Model-Based Approach Poster Susan Willavize*, Miia Kivipelto, D Larry Sparks, Roy W Jones, Andrei Breazna, David A DeMicco, Judith Hey-Hadavi, Rachel J Schindler, and Brian Corrigan  Disease Modeling
Rujia Xie Population Pharmacokinetic/Pharmacodynamic (PK/PD) Analysis for the Effect of Tanezumab on Overall Daily Pain Score Data in Adults with Moderate-to-Severe Pain due to Osteoarthritis of the Knee Poster Rujia Xie*, Rosalin Arends, Stephen Olson, Scott Marshall  Exposure-Response
Huafeng Zhou A Bayesian Approach to Handle Pharmacodynamics (PD) Data Below Limit of Quantification (BLOQ) in PK/PD Modeling  poster Huafeng Zhou, Alan Hartford, Kuenhi Tsai Tools and Techniques
Susan Zhou Feasibility of Characterizing Time and Concentration Dependent Binary Response Data by Time-To-Event Analysis  poster Zexun Zhou*, Xiaoning Wang, Marc Pfister, Amit Roy Exposure-Response
Rui Zhu Isoniazid Pharmacokinetics in HIV Perinatally Exposed Infants: The Role of NAT-2 Enzyme Maturation Poster R. Zhu*, J. Kiser, S. Nachmann, C. Mitchell, G. McSherry, S. Madhi, M. Cotton, R. Bobat, S. Kim, H. Seifart, C. Werely, D. Z. D’Argenio, C. V. Fletcher Pediatrics