Monolix 4.2 Workshop

Date:  Thursday, May 16 and Friday, May 17, 2013

Registration Fees:
Non-trainee ISoP members: $950
Trainee ISoP members: $200
ISoP non-members: $1550

Sponsor: Lixoft

Instructors/Teaching Assistants: Marc Lavielle

Workshop summary:   Monolix is a platform mainly dedicated to PK/PD modeling. It features a user-friendly interface, with powerful algorithms and impressive runtimes. It is fit for extensive deployment in any pharmaceutical data workflow, from preclinical studies to final submission. It runs on Windows and Linux operating systems, on standalone workstations as well as clusters.

Monolix is associated with MLXTRAN, an easy and powerful declarative script language for programming simple and complex pharmacometric models, including models for continuous data, categorical data, count data, time-to-event data… Complete Monolix projects can be entirely implemented in MLXTRAN, including full GUI programing & configuration, workflows, graphics settings and generations, ... MLXTRAN does not require Monolix, and MLXTRAN code can also be used as a function from Matlab and R. MLXPLORE is a new graphical and interactive tool for exploring pharmacometric and statistical models. It allows to perform sensitivity analysis, to visualize complex dynamical systems, to evaluate the impact of the inter individual variability on the variability of the outcomes of the model,...

The workshop will provide a complete presentation of the latest version Monolix 4.2. The algorithms used in Monolix and several advanced features for modeling will be presented (Bayesian estimation, mixture models, flexible censoring processes, extensive diagnostic plots,…). The course will also include training on MLXTRAN and MLXPLORE.

The course will emphasize hands on training, with participants working on their own computers with Monolix 4.2 installed. Monolix is free for academics, students and regulation agencies. Other participants to the workshop will be provided a three months license of a full-featured version of Monolix 4.2.  Attendees are expected to have previous experience with population PK-PD modeling.

Preliminary schedule: Note, specific times are subject to change based on alignment with concurrent ACoP workshops

Day 1
8:30 am Introduction to Monolix
10:15 am Coffee/Tea Break
10:30 am Hands on 1: PK model, diagnostic plots, model selection
12:00 pm Lunch
1:30 pm The algorithms used in Monolix
2:00 pm Advanced features for PK: IOV, Steady-State, BLQ data
3:00 pm Coffee/Tea Break
3:15 pm Hands on 2: SAEM, hypothesis testing, PKPD model
4:30 pm End of Day 1

Day 2
8:30 am MLXTRAN for PK and PK-PD data
10:15 am Coffee/Tea Break
10:30 am Hands on 3: MLXTRAN for PK and PK-PD data - I
12:00 pm Lunch
1:30 pm Mixture models and model mixtures
2:00 pm Modelling categorical data, count data and time to event data 
3:00 pm Coffee/Tea Break
3:15 pm MLXPLORE, a new tool for exploring complex models
3:30 pm Hands on 4: MLXTRAN for PK and PK-PD data - II
4:30 pm End of the course