| SATURDAY APRIL 2 and SUNDAY APRIL 3 |
| Pre-meeting workshops (click for more info) |
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SUNDAY APRIL 3
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| 12:00 PM |
5:00 PM |
Registration |
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| 7:00 PM |
9:00 PM |
ACoP Opening Reception |
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| MONDAY APRIL 4 |
| 7:30 AM |
8:30 AM |
Breakfast/Registration |
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| 8:30 AM |
8:40 AM |
Welcome/Program Overview |
Marc Gastonguay, Raymond Miller |
| 8:40 AM |
9:00 AM |
Introducing ASoP! |
Stacey Tannenbaum, Marc Pfister |
| 9:00 AM |
10:00 AM |
Lewis B. Sheiner Lecture |
Nancy Sambol
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Estimating Dose-Response in a Trial Randomizing Only Treatment Versus Control Utilizing Varying Compliance in Both Arms |
Don Rubin |
| 10:00 AM |
10:30 AM |
Break/Posters/Exhibits |
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| 10:30 AM |
12:00 PM |
Session 1: Mechanistic Modeling in Oncology Drug Development
[Suggested reading]
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Diane Mould, Dinesh De Alwis, Jeroen Elassaiss-Schaap |
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Introduction |
Dinesh De Alwis |
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The Added Value of Mechanistic Models to Drug Development |
Orna Amir |
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Tumor Vessel Dynamics During Anti-Angiogenic Therapy |
Lance Munn |
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"What Is the Question?” Thoughts for PK/PD Experts from a Clinical Immunotherapist |
Richard Junghans |
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Summary and Closing Remarks |
Jeroen Elassaiss-Schaap |
| 12:00 PM |
1:30 PM |
Lunch/Posters/Exhibits
Student Mentoring Session
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| 1:30 PM |
3:00 PM |
Session 2: ACoP Poster-Podium and Presentation of Awards |
Julie Stone, Bojan Lalovic, Hao Zhu
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Population Modeling of Long-Term Steroid-induced Bone Loss in Patients Undergoing Hematopoietic Stem Cell Transplantation |
Hong Li |
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Disease Progression Model for Multiple Sclerosis and effect of Cladribine Tablets Therapy on Clinical Endpoints |
Radojka Savic |
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Disease model of the synovium in Rheumatoid Arthritis. Is it a relevant contribution to Phase 2 design? |
Rune Overgaard |
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Modeling of Functional Assessment Questionnaire (FAQ) as Continuous Bounded Data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Database |
Kaori Ito |
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Impact of Various Clinical Practice Strategies on Cardiovascular Risk for the Treatment of Hypertension: A Clinical Trial Simulation Study |
Yuyan Jin |
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Award presentations |
France Mentre, Marc Pfister |
| 3:00 PM |
4:30 PM |
Poster Session #1 and Exhibits |
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| 4:30 PM |
7:00 PM |
Free Time |
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| 7:00 PM |
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Social Event |
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| TUESDAY APRIL 5 |
| 7:30 AM |
8:30 AM |
Breakfast |
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| 8:30 AM |
10:00 AM |
Session 3: Heart Failure: Pathophysiology and Quantitative Modeling |
Anna Georgieva, Chee Ng |
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Pathophysiology of Heart Failure |
Shi-Yin Foo
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The Cardiovascular-Renal platform: a large-scale mechanistic model for evaluating the effects of antihypertensive agents on chronic heart failure
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Melissa Hallow |
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Whole-heart modeling of heart failure |
Natalia Trayanova |
| 10:00 AM |
10:30 AM |
Break/Posters/Exhibits |
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| 10:30 AM |
12:00 PM |
Session 4: Pharmacometrics in Pregnancy: Quantifying Maternal/Fetal Pharmacology
[Suggested reading]
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Coen van Hasselt, Marilee Andrew
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Introductory Remarks |
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Pharmacometrics in Pregnancy: the Unmet Need |
Mary F. Hebert |
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Population Pharmacokinetics of Antimalarial Drugs in Pregnant Women |
Joel Tarning |
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Exploring Maternal/Fetal Exposure with Physiologically Based Models |
Donald R. Mattison |
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Closing remarks |
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| 12:00 PM |
1:30 PM |
Lunch/Posters/Exhibits |
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| 1:30 PM |
3:00 PM |
Session 5: Modeling and Simulation in Neurodegenerative Diseases
[Suggested reading]
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Parviz Ghahramani |
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Clinical Challenges in Neurodegeneration |
Lon Schneider |
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Learning from Prior Alzheimer's Disease Clinical Trials |
Hao Zhu |
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Model-based Trial Optimization for Phase II and III designs in Alzheimer's Disease |
Andrew Hooker |
| 3:00 PM |
4:30 PM |
Poster Session #2 and Exhibits |
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| 4:30 PM |
8:00 PM |
Free Time
Dinner on your own |
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| 8:00 PM |
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Dessert bar
Posters/exhibitors |
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| WEDNESDAY APRIL 6 |
| 7:30 AM |
8:30 AM |
Breakfast |
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| 8:30 AM |
10:00 AM |
Session 6: Impact of Pharmacometrics in Patient Care |
Roger Jeliffe, Michael Neely |
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Pharmacometric Applications to Immunosuppressive Therapy in Transplant Patients |
Sander Vinks |
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Use of Statistical Process Control Theory and Effect-Control Hemodynamics to Guide the Management of Sodium
Nitroprusside for Controlled Hypotension in Children |
Jeffrey Barrett |
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Multiple Model Approach to Individual Dose Optimization |
Michael Neely |
| 10:00 AM |
10:30 AM |
Break/Posters/Exhibits |
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| 10:30 AM |
12:00 PM |
Session 7: Tutorial: Using Model-Based Meta-Analysis to Inform Drug Development Decisions
[Suggested reading]
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Jonathan French |
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Meta-analysis for Longitudinal Dose-response Characterization in Alzheimer's Disease: a Bayesian modeling framework for combining individual and summary-level dat |
James Rogers |
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Network meta-analysis: concepts, assumptions and application to repeated measures |
Jeroen P Jansen |
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Using a model-based meta-analysis for comparative effectiveness evaluations |
Jaap Mandema |
| 12:00 PM |
2:00 PM |
Box Lunch
Poster Session #3 and Exhibits |
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| 2:00 PM |
3:30 PM |
Session 8: Advancements and Applications of Multiscale Systems Pharmacology Modeling
[Suggested reading]
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Wojciech Krzyzanski, Mark C. Peterson |
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A Model for Combination Rituximab Therapy Based on Receptor Occupancy Driven Molecular Signal
Transduction in Non-Hodgkin's Lymphoma |
John Harrold |
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A Physiologically-Based, Multi-Scale, Mathematical Model of Integrated Calcium Homeostasis and Bone Remodeling |
Matthew Riggs |
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A Comprehensive Model for the Humoral Coagulation Network |
Stephen Duffull |
| 3:30 PM |
4:00 PM |
Closing Remarks |
Stacey Tannenbaum |
| 4:00 PM |
7:00 PM |
Beach Party |
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THURSDAY APRIL 7
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| Post-meeting workshops (click for more info) |
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